The laboratory of biophysics of excitable systems was established at MIPT in the end of 2010 as one of the laboratories of the “mega-grant” program of the Russian Government (http://www.p220.ru/). The main focus of the laboratory is the investigation of excitable biological tissues, such as cardiac tissue. For that purpose, methods for optical mapping of biological samples and tissue engineering techniques are being developed in the laboratory.
List of laboratories
The laboratory conducts research in the following areas: molecular genetic mechanisms of aging and lifespan, treatment of age-dependent pathologies with advanced target proteins, and geroprotective characteristics of various substances. The research employs methods of molecular and classical genetics with the use of various model systems (yeast, drosophila, mice, human cells, long-lived mammals and fish species), bioinformatics and systems biology. The laboratory conducts analysis of genomes and transcripts of animal species and model systems with delayed-aging and increased lifespan traits.
The laboratory conducts research in the following areas: interaction modeling in protein ligands, toxicity predicting, and QSAR modeling. The laboratory has engineered and implemented Smart Mining - a unique software system for studies in computational chemistry. The laboratory employs Kohonen artificial neural networks to predict specific target activity of compounds and their characteristics, such as CYP3A4 (Cytochrome P450) binding, hematoencephalic barrier permeation, plasma protein binding, acute toxicity, plasma half-life, etc.
The laboratory conducts research in tissue engineered bioconstruction with targeted organ or tissue replacement functions. The process of bioconstruction involves tackling a number of interdependent issues, such as creating a brassboard of a two-circuit perfusion system meant for artificial revitalization of an extracellular biological, combined, or artificial matrix; developing a vascular graft based on a revitalized, homogeneous, collagen and elastic matrix; developing sustained release peptide-based drugs from defined and standardized mesenchymal stem cells cultivated in ex vivo expansion conditions.
The lab conducts both fundamental and applied research including search and validation of new targets and new approaches for the development of new drugs and plant protection methods. High-content screening and analysis of live cell digital images compose basic technological platform for fundamental research on aging and age-related pathologies, preclinical studies of drug candidates against various diseases including carcinogenesis, inflammation, Alzheimer’s and Parkinson’s diseases. There are two Doctors of Sciences and seven PhDs working in the lab.
Laboratory of Computer and Mathematical Modeling of Biological Systems was founded in Moscow Institute of Physics and Technology in 2016. It is lead by Artem Zhmurov, Philipp Orekhov and Valeri Barsegov, a visiting professor from University of Massachusetts at Lowell
Laboratory web-page: http://hpc.mipt.ru/zhmurov/lab/
Laboratory webpage: http://ipavlov.ai/
MIPT’s Neural Networks and Deep Learning Lab was established in 2015 to carry out fundamental and applied research into neural systems and deep learning mechanisms, aimed at creating artificial intelligence. This work involves the development of new algorithms capable of identifying a sequence of actions that will lead to the solution of a problem in an unknown environment without any supervision. Achieving this will make AI systems significantly more autonomous, expanding the range of their possible applications.
The Laboratory of systems biology conducts the researches in the sphere of the problems of data integration of transcriptional, proteomic and metabolic activity of the genome of biological objects. In the research projects carried out in the sphere of post-genomic biology and medicine, not only information about the complete DNA sequence of the studied object is used, but also the persistence of the genome is studied, its micro- and macroheterogeneity is described as well as cause-and-effect relationships that occur in case of the DNA instability on the level of matrix RNA and proteins.
The Nanobiotechnology Lab conducts research in many fields but has a primary focus on the development of smart materials based on nanoparticles and their in vitro and in vivo applications. The equipment available at the laboratory enables it to conduct a full cycle of nanobiotechnological research. This includes synthesizing inorganic nanoparticles, covering them with polymers, and testing the interaction of nanomaterials with inanimate objects, cells, and animal tissues.