The laboratory of biophysics of excitable systems was established at MIPT in the end of 2010 as one of the laboratories of the “mega-grant” program of the Russian Government (http://www.p220.ru/). The main focus of the laboratory is the investigation of excitable biological tissues, such as cardiac tissue. For that purpose, methods for optical mapping of biological samples and tissue engineering techniques are being developed in the laboratory.
List of laboratories
The laboratory conducts research in the following areas: molecular genetic mechanisms of aging and lifespan, treatment of age-dependent pathologies with advanced target proteins, and geroprotective characteristics of various substances. The research employs methods of molecular and classical genetics with the use of various model systems (yeast, drosophila, mice, human cells, long-lived mammals and fish species), bioinformatics and systems biology. The laboratory conducts analysis of genomes and transcripts of animal species and model systems with delayed-aging and increased lifespan traits.
The laboratory conducts research in the following areas: interaction modeling in protein ligands, toxicity predicting, and QSAR modeling. The laboratory has engineered and implemented Smart Mining - a unique software system for studies in computational chemistry. The laboratory employs Kohonen artificial neural networks to predict specific target activity of compounds and their characteristics, such as CYP3A4 (Cytochrome P450) binding, hematoencephalic barrier permeation, plasma protein binding, acute toxicity, plasma half-life, etc.
The laboratory conducts research in tissue engineered bioconstruction with targeted organ or tissue replacement functions. The process of bioconstruction involves tackling a number of interdependent issues, such as creating a brassboard of a two-circuit perfusion system meant for artificial revitalization of an extracellular biological, combined, or artificial matrix; developing a vascular graft based on a revitalized, homogeneous, collagen and elastic matrix; developing sustained release peptide-based drugs from defined and standardized mesenchymal stem cells cultivated in ex vivo expansion conditions.
The Laboratory for the Development of Innovative Drugs conductsvalidation testing of approaches developed by Sharpless that aim to significantly improve the quality of drugs that affect biological and metabolic processes in the cell. New methods are based on the use of innovative click-chemistry, which is researched on different cell models, including carcinogenesis, inflammation and Alzheimer's and Parkinson's diseases. There is one doctor of sciences and six candidates of sciences among the staff working in the laboratory.
The Laboratory of systems biology conducts the researches in the sphere of the problems of data integration of transcriptional, proteomic and metabolic activity of the genome of biological objects. In the research projects carried out in the sphere of post-genomic biology and medicine, not only information about the complete DNA sequence of the studied object is used, but also the persistence of the genome is studied, its micro- and macroheterogeneity is described as well as cause-and-effect relationships that occur in case of the DNA instability on the level of matrix RNA and proteins.