Systems Biology Lab

The Laboratory of systems biology conducts the researches in the sphere of the problems of data integration of transcriptional, proteomic and metabolic activity of the genome of biological objects. In the research projects carried out in the sphere of post-genomic biology and medicine, not only information about the complete DNA sequence of the studied object is used, but also the persistence of the genome is studied, its micro- and macroheterogeneity is described as well as cause-and-effect relationships that occur in case of the DNA instability on the level of matrix RNA and proteins.

A key condition of the systems biology projects is a creation of a technological complex of methods, the so-called technological platform, which will allow to carry out researches at four levels of the cell organization, i.e. to define the stability parameters of the genome of the studied object (full genome sequencing), to determine the level of gene transcription (transcription profile), to measure the proteins expression and their post-translational modification (proteomic profile), as well as to register the flows of metabolites. 
The Laboratory was founded in 2013 as a part of the MIPT Life Sciences Center for the research of omix human data for the needs of medicine, biotechnological industry, knowledge generation in the field of life sciences, and for the search of new drug compounds. 

Current Projects 
The study of the M.gallisepticum proteome in the stress conditions and the study of Hu-protein activity in Ecoli bacteria.

Vadim M. Govorun

Head of Systems Biology Lab

Professional experience
Vadim Markovich Govorun — the Head of the Laboratory, Doctor of Biological Sciences, Professor and the Correspondent Member of the Russian Academy of Medical Sciences.
Academic Interests

Elena S. Kostryukova

Senior research scientist

Professional experience
Elena Sergeyevna Kostryukova — the Deputy Head of the Laboratory, senior research scientist, Candidate of Biological Sciences
Academic Interests

Dmitry G. Alekseev

Senior research scientist

Professional experience
Dmitry Glebovich Alekseev — the Deputy Head of the Systems Biology Lab, senior research scientist, Candidate of Biological Sciences
Academic Interests

Igor A. Fesenko

Senior research scientist

Professional experience
Igor Aleksandrovich Fesenko — senior research scientist, Candidate of Biological Sciences
Academic Interests