Nanobiotechnology Lab

The Nanobiotechnology Lab conducts research in many fields but has a primary focus on the development of smart materials based on nanoparticles and their in vitro and in vivo applications. The equipment available at the laboratory enables it to conduct a full cycle of nanobiotechnological research. This includes synthesizing inorganic nanoparticles, covering them with polymers, and testing the interaction of nanomaterials with inanimate objects, cells, and animal tissues.

Main lines of research:

• Materials science: colloid chemistry (nanoparticle synthesis and functionalization), fine chemical synthesis, microscopy, and tomography.

• Physical sensoric systems: development and use of new optical and magnetic biosensors for researching intermolecular interactions and ultrasensitive detection of magnetic materials, including in vivo detection.

• Nanobiosensotics: development of new ultrasensitive nanoparticle-based methods for rapid identification of molecules, including toxins, herbicides, and drugs.

• Biocomputing and nanorobotics: work on the fundamental principles for building molecular automata and nanorobots, and their application.

• Biotech: genetic engineering, hybrid technologies, and cell technologies.

• Theranostics: development of new-generation drug delivery systems based on biocomputer structures capable of independent analysis.

Maxim Nikitin

Head of laboratory, senior researcher

Education
12/13 Ph.D. in Physical and Mathematical Sciences (Institute of Molecular Biology RAS; Moscow Institute of Physics and Technology Ph.D. programm)
09/04 – 06/08 M.Sc. with Honors in Applied Physics and Mathematics (Physical and Chemical Biology minor), Moscow Institute of Physics and Technology, Moscow, Russia
Professional experience
Research Positions
-12/14 – present Head of Nanobiotechnology Laboratory, Moscow Institute of Physics and Technology, Moscow, Russia
- Senior Researcher, General Physics Institute, RAS, Moscow, Russia
- Senior Researcher, Institute of Bioorganic Chemistry, RAS, Moscow, Russia

Research experience in external laboratories
Researcher:

10/13 – 03/14 Argonne National Laboratory, USA (Dr. Novosad group)
07/08 Technical University of Munich, Germany (Prof. Ch. Plank group)
12/07 Lund University, Lund, Sweden (Dr. Ivanov group)
07/07 – 08/07 University of Buffallo, Buffalo, USA (group of Distinguished Prof. P. Prasad)
07/06 University of Chicago, NeuroICU/Rosengart Labs, USA (Dr. Rosengart group)
04/06 – 05/06 Inst. Pharm. Chem., Philipps University, Marburg, Germany (Prof. Keusgen group)
Academic Interests
Major scientific interests are in the field of nano-sized objects and their interaction with biological entities such as cells and living organisms, in particular, synthesis of inorganic particles, coating them with biopolymers, proteins and DNA; self-assembly of multifunctional superstructures via biomolecular interfaces; development of nanoparticle based smart materials; logic-gated and biocomputing structures; biomedical applications of biocompatible nanomaterials such as targeted drug delivery, cell sorting and labeling, hyperthermia of tumors; new label-free optical bio- and chemical sensors for advanced immunoassays; low-noise methods for detection of magnetic nanoparticles in vivo for investigation of nanoparticle behavior in experimental animals, i.e., their toxicity, biotransformation and biodegradation.
Publications

2014, NATURE NANOTECHNOLOGY (34.048)

2013, APPLIED BIOCHEMISTRY AND MICROBIOLOGY (0.735)

2010, 8TH INTERNATIONAL CONFERENCE ON THE SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS

2010, 8TH INTERNATIONAL CONFERENCE ON THE SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS

2010, Proceedings of the National Academy of Sciences (9.674)

2007, International Conference on Lasers, Applications, and Technologies

Contacts
Phone +7 (916) 662-10-88
Email max.nikitin@gmail.com

Vladimir Cherkasov

Deputy Head of Laboratory

Education
PhD in chemistry
Contacts
Phone +7-910-478-22-82
Email v_r_cherkasov@list.ru

Olga Prushinskaya

Lab assistant

Andrey Tregubov

Senior researcher

Education
Postdoc

Viktoriya Shipunova

Engineer

Education

Postdoc

PhD in biology

Konstantin Shevchenko

Junior researcher

Education

Doctoral student

Ivan Zelepukin

Engineer

Education
Doctoral student

Ilya Sokolov

Engineer

Education
Doctoral student

Andrey Babenyshev

Engineer

Education
Graduate student

Alexandra Vasilyeva

Engineer

Education
Graduate student

Afanasy Lunin

Engineer

Education
Graduate student

Elizaveta Mochalova

Engineer    

Education
Graduate student

Alexey Yaremenko

Engineer

Education
Graduate student

Stanislav Buyukli

Education
Graduate student

Polina Kotelnikova

Education

Graduate student

Valentin Melnikov

Education
Graduate student

Aziz Mirkamysov

Education
Graduate student

Darya Silantyeva

Education
Graduate student

Averyan Pushkarev

Education

Graduate student

2014

Journal of Aerosol Science

Generation and delivery of nanoaerosols from biological and biologically active substances

V.N. Morozov, I.L. Kanev, A.Y. Mikheev, E.A. Shlyapnikova, Y.M. Shlyapnikov, M.P. Nikitin, P.I. Nikitin, A.O. Nwabueze, M.L. van Hoek

48-61 page

Moscow Institute of Physics and Technology

Hyperfine Interactions

Mössbauer evidence of 57Fe3O4 based ferrofluid biodegradation in the brain

D. Polikarpov, V. Cherepanov, M. Chuev, R. Gabbasov, I. Mischenko, M. Nikitin, Y. Vereshagin, A. Yurenia, V. Panchenko

421-430 page

Moscow Institute of Physics and Technology

Nature Nanotechnology

Biocomputing based on particle disassembly

M.P. Nikitin, V.O. Shipunova, S.M. Deyev, P.I. Nikitin

716-722 page

Moscow Institute of Physics and Technology

2015

Solid State Phenomena

Combined Photodynamic Thermochemotherapy of Glial Tumors Controlled by MRI and Electronic Sensor

N.A. Brusentsov, V.A. Polianskiy, A.V. Zhukov, M.V. Gulyaev, M.P. Nikitin, P.I. Nikitin, T.N. Brusentsova, V.D. Kuznetsov, O.A. Bocharova, A.Yu. Baryshnikov

757-760 page

Moscow Institute of Physics and Technology

Journal of Magnetism and Magnetic Materials

A new real-time method for investigation of affinity properties and binding kinetics of magnetic nanoparticles

A.V. Orlov, M.P. Nikitin, V.A. Bragina, S.L. Znoyko, M.N. Zaikina, T.I. Ksenevich, B.G. Gorshkov, P.I. Nikitin

231-235 page

Moscow Institute of Physics and Technology

Journal of Magnetism and Magnetic Materials

Mössbauer study of exogenous iron redistribution between the brain and the liver after administration of 57Fe3O4 ferrofluid in the ventricle of the rat brain

Polikarpov D., Gabbasov R., Cherepanov V., Loginova N., Loseva E., Nikitin M., Yurenia A., Panchenko V.

78-84 page

Moscow Institute of Physics and Technology

Analytical and bioanalytical chemistry

Direct immunosensing by spectral correlation interferometry: assay characteristics versus antibody immobilization chemistry

A.G. Burenin, A.E. Urusov, A.V. Betin, A.V. Orlov, M.P. Nikitin, T.I. Ksenevich, , B.G. Gorshkov, A. V. Zherdev, B.B. Dzantiev, P.I. Nikitin

3955-3964 page

Moscow Institute of Physics and Technology

Biochemistry and Biophysics

A comprehensive study of interactions between lectins and glycoproteins for the development of effective theranostic nanoagents

V.O. Shipunova, M.P. Nikitin, I.V. Zelepukin, P.I. Nikitin, S.M. Deyev, R.V. Petrov

315-318 page

Moscow Institute of Physics and Technology

2016

Nanoscale

MPQ-Cytometry: a Magnetism-Based Method for Quantification of Nanoparticle-Cell Interactions

V.O. Shipunova, M.P. Nikitin, P.I. Nikitin, S.M. Deyev

12764-12772 page

Moscow Institute of Physics and Technology

Biosensors and Bioelectronics

Rapid dry-reagent immunomagnetic biosensing platform based on volumetric detection of nanoparticles on 3D structures

A.V. Orlov, V.A. Bragina, M.P. Nikitin, P.I. Nikitin

423-429 page

Moscow Institute of Physics and Technology

Biochemistry and Biophysics

Synthesis of magnetic silica nanomarkers with controlled physicochemical properties

I.V. Zelepukin, M.P. Nikitin, V.R. Cherkasov, P.I. Nikitin, S.M. Deyev, P.V. Petrov

335-337 page

Moscow Institute of Physics and Technology

Analytical Chemistry

Multiplex Biosensing Based on Highly Sensitive Magnetic Nanolabel Quantification: Rapid Detection of Botulinum Neurotoxins A, B, and E in Liquids

A.V. Orlov, S.L. Znoyko, V.R. Cherkasov, M.P. Nikitin, P.I. Nikitin

10419-10426 page

Moscow Institute of Physics and Technology

Journal of Magnetism and Magnetic Materials

Exogenous iron redistribution between brain and spleen after the administration of the 57 Fe 3 O 4 ferrofluid into the ventricle of the brain

R. Gabbasov, D. Polikarpov, V. Cherepanov, M. Chuev, I. Mischenko, N. Loginiva, E. Loseva, M. Nikitin, V. Panchenko

Moscow Institute of Physics and Technology

Hyperfine Interactions

Mössbauer and X-ray study of biodegradation of 57Fe3 O 4 magnetic nanoparticles in rat brain

R.R. Gabbasov, V.M. Cherepanov, M.A. Chuev, A.A. Lomov, I.N. Mischenko, M.P. Nikitin, M.A. Polikarpov, V.Y. Panchenko

1-12 page

Moscow Institute of Physics and Technology

Sensors and Actuators B: Chemical

Highly reproducible and sensitive detection of mycotoxins by label-free biosensors

A.V. Orlov, A.G. Burenin, N.G. Massarskaya, A.V. Betin, M.P. Nikitin, P.I. Nikitin

Moscow Institute of Physics and Technology

2017

Biochimica et Biophysica Acta (BBA)

Smart materials on the way to theranostic nanorobots: molecular machines and nanomotors, advanced biosensors, and intelligent vehicles for drug delivery

I.L. Sokolov, V.R. Cherkasov, A.A. Tregubov, S.R. Buiucli, M.P. Nikitin

Moscow Institute of Physics and Technology

Biosensors and Bioelectronics

Surface plasmon resonance as a tool for investigation of non-covalent nanoparticle interactions in heterogeneous self-assembly & disassembly systems

K.G. Shevchenko, V.R. Cherkasov, A.A. Tregubov, P.I. Nikitin, M.P. Nikitin

3-8 page

Moscow Institute of Physics and Technology

The Institute of Bioorganic Chemistry (RAS)

Prokhorov General Physics Institute (RAS)