Aging and Lifespan Genetics Lab

The laboratory conducts research in the following areas: molecular genetic mechanisms of aging and lifespan, treatment of age-dependent pathologies with advanced target proteins, and geroprotective characteristics of various substances. The research employs methods of molecular and classical genetics with the use of various model systems (yeast, drosophila, mice, human cells, long-lived mammals and fish species), bioinformatics and systems biology. The laboratory conducts analysis of genomes and transcripts of animal species and model systems with delayed-aging and increased lifespan traits.

Agreement with the Buck Institute for Research on Aging (California, USA). The studying of the causes and mechanisms of aging on different levels of the living organisms organization and the development of biomedical issues for the regulation of this process are fundamental scientific problems. The understanding of the nature of the aging process will allow people to control over longevity, to develop the preventive measures against premature aging and development of aging-associated diseases. 

The laboratory activity is aimed at the search of genetic, epigenetic and physiological mechanisms of aging and longevity as well as at the search of substances and gene-therapy interventions able to slow down the aging process, to increase longevity and stress resistance of organisms by the influence on pathologic gene networks. Nowadays, the laboratory is the only laboratory in Russia, which fully focuses on biogerontology. 

The laboratory researches are based on classical methods of molecular and cellular biology, new generation sequencing, the methods of work with laboratory animals, bioinformatics and mathematic modelling.

Alexey A.Moskalev

Head of laboratory

The Buck Institute for Research on Aging