Laboratory of Structural Biology of G-protein Coupled Receptors

The Laboratory of Structural Biology of G-protein Coupled Receptors focuses on structural and functional studies of G-protein coupled receptors (GPCR). We use a multidisciplinary structural-biological approach in which we combine computer methods with a wide range of biophysical methods (crystallography, the fluorescence of single molecules, electron microscopy, NMR, mass spectrometry, etc.) to find answers to questions concerning the mechanisms of ligand recognition and signal transmission in GPCR.
To carry out this activity, the laboratory works in close cooperation with leading research centers in Europe, the United States, and China.

Activity in the Laboratory of Structural Biology of G-protein Coupled Receptors is focused on structural and functional research of G-protein Coupled Receptors (GPCR). We apply a multi-disciplinary, structural biological approach in which we combine computational methods with numerous biophysical techniques (crystallography, fluorescence of single molecules, electron microscopy, NMR, mass spectrometry, etc.) in order to find an answer to questions concerning the mechanisms of ligand recognition and signal transfer in GPCR. This project conducts a focused and comprehensive structure-function research on highly important but previously untackled targets from the GPCR superfamily. The results of these studies will provide scientists with essential information for designing new generation drugs with higher efficacy and minimal side effects.

Vadim Cherezov

Head of the laboratory

Alexey Mishin

Deputy head

Petr Popov

Computational group leader

Alexandra Luginina

Researcher

Polina Khorn

Researcher

Mikhail Shevtsov

Senior researcher

Anastasia Gusach

PhD student

Elizaveta Lyapina

PhD student

Nadezda Safronova

PhD student

Georgiy Khusainov

PhD student