Biomedical Engineering Lab

The laboratory conducts research in tissue engineered bioconstruction with targeted organ or tissue replacement functions. The process of bioconstruction involves tackling a number of interdependent issues, such as creating a brassboard of a two-circuit perfusion system meant for artificial revitalization of an extracellular biological, combined, or artificial matrix; developing a vascular graft based on a revitalized, homogeneous, collagen and elastic matrix; developing sustained release peptide-based drugs from defined and standardized mesenchymal stem cells cultivated in ex vivo expansion conditions.

About

Main lines of research:

• Biomechanics of the cardiovascular system, breathing.

• Development of artificial organs.

• Biomechanics of motion activity.

• Biophysics of cell processes.

• Development of tissue-engineered biostructures with desired organ or tissue replacement functions.

• Research on central neural mechanisms enabling the human motion control system in healthy individuals and patients with motion pathologies.

• Development of single-use medical devices for sampling blood and obtaining its components.

• Development of medical devices for therapeutic and donoral membrane plasmapheresis, hemo- and liquor-sorbtion and detoxification of biological liquids.

• Preclinical and clinical tests of medical devices.

Our team

Valeriy Zaiko

Head of laboratory

Mogeliya Khubutiya

Scientific supervisor
Georgiy Guriya
Artur Melkumyants
Alexander Dyachenko
Georgiy Itkin
Yuri Levik
Vladimir Abramov
Alexei Sedov
Igor Sarkisov

Valeriy Zaiko

Head of laboratory

Education

Associate professor

PhD in physics and mathematics

Professional experience
Supervisor of the medical devices testing center at the Shumakov Federal Research Center of Transplantology and Artificial Organs

Mogeliya Khubutiya

Scientific supervisor

Education

Professor

Member of the Russian Academy of Sciences

ScD in medicine

Professional experience
Director of the Sklifosovsky Research Institute for Emergency Medicine, Moscow

Georgiy Guriya

Education

Professor

ScD in physics and mathematics

Professional experience
Head of the Mathematical Modeling Lab in the Scientific Center for Hematology of the Russian Ministry of Healthcare

Artur Melkumyants

Education

Professor

ScD in biology

Professional experience

Leading researcher at the physiology department of the Russian Cardiology Research and Production Complex of the Russian Ministry of Healthcare

Alexander Dyachenko

Education

Professor

ScD in engineering

Professional experience

Head of laboratory at the General Physics Institute of the Russian Academy of Sciences (RAS)

Georgiy Itkin

Education

Professor

ScD in biology

Professional experience

Head of the Biotechnical Systems Laboratory at the the Shumakov Federal Research Center of Transplantology and Artificial Organs of the Russian Ministry of Healthcare

Yuri Levik

Education

Associate professor

ScD in biology

Professional experience
Head of the Motion Control Neurobiology Laboratory at the Kharkevich Institute for Information Transmission Problems, RAS

Vladimir Abramov

Education

Associate professor

PhD in biology

Professional experience
Head of the Bioelectrochemistry Laboratory at the Frumkin Physical Chemistry and Electrochemistry Institute, RAS

Alexei Sedov

Education

Associate professor

PhD in biology

Professional experience
Head of the Laboratory of Human Cell Neurophysiology at the Semenov Institute of Chemical Physics, RAS

Igor Sarkisov

Education
PhD in biology
Professional experience
CEO of Biotech-M, a blood detoxification equipment manufacturer

Publications

2014

Journal of Fluids and Structures (2.021)

Fluid trapping by two partially shrouded rotating cylinders

Dudchenko O.A., Zolotavin P.N., Guria G.Th.

87-96 page

Moscow Institute of Physics and Technology

Thrombosis Research (2.32)

Real-Time Monitoring of Blood Coagulation and Fibrinolysis

D. Ivlev, K. Guria, S. Uzlova, S. Dzhumaeva, G. Guria Th.

Moscow Institute of Physics and Technology

Protection of Metals and Physical Chemistry of Surfaces

Superhydrophobization of low-carbon steel with conversion coatings

Alpysbaeva, D. A., Vershok, D. B., Emel’yanenko, A. M., Batishchev, O. V., Kuznetsov, Y. I., Boinovich, L. B.

898-902 page

Moscow Institute of Physics and Technology

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

Isoprenoid lipid chains increase membrane resistance to pore formation

Panov, P. V., Akimov, S. A., Batishchev, O. V.

304-308 page

Moscow Institute of Physics and Technology

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

Line tension and structure of through pore edge in lipid bilayer

Akimov, S. A., Mukovozov, A. A., Voronina, G. F., Chizmadzhev, Y. A., Batishchev, O. V.

297-303 page

Moscow Institute of Physics and Technology

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

Model of membrane fusion: Continuous transition to fusion pore with regard of hydrophobic and hydration interactions

Akimov, S. A., Molotkovsky, R. J., Galimzyanov, T. R., Radaev, A. V., Shilova, L. A., Kuzmin, P. I., Batishchev, O. V., Voronina, G. F., Chizmadzhev, Y. A.

153-161 page

Moscow Institute of Physics and Technology

Biophysical Journal

Mechanisms of Self-Assembly and Dissection of Influenza A Virus Protein Scaffold

Batishchev, O. V., Shilova, L. A., Tashkin, V. Y., Sokolov, V. S., Chizmadzhev, Y. A.

Moscow Institute of Physics and Technology

Annals of Biomedical Engineering

Use of input impedance to determine changes in the resistance of arterial vessels at different levels in feline femoral bed

Naumov A.Yu., Balashov S.A., Melkumyants A.M.

1644-1657 page

Moscow Institute of Physics and Technology

Biochemistry

Malonyldialdehyde and glyoxal act differently on low-density lipoproteins and endotheliocytes

Elena M. Kumskova, Olga A. Antonova, Sergey A. Balashov, Alla K. Tikhaze, Arthur M. Melkumyants, Vadim Z. Lankin

79-85 page

Moscow Institute of Physics and Technology

Movement disorders

Neural mechanisms of sensory and motor signals transmission in the interstitial nucleus of Cajal in patients with spasmodic torticollis

A.S. Sedov, R.S. Medvednik, S.N. Raeva

S201-S202 page

Moscow Institute of Physics and Technology

2015

Thrombosis Research (2.32)

Spatial aspects of blood coagulation: Two decades of research on the self-sustained traveling wave of thrombin

Guria K.G., Guria G.Th.

Moscow Institute of Physics and Technology

PLoS ONE (4.411)

Mathematical Modeling of Intravascular Blood Coagulation under Wall Shear Stress

Rukhlenko O.S., Dudchenko O.A., Zlobina K.E., Guria G.Th.

Moscow Institute of Physics and Technology

Journal of Thrombosis and Haemostasis (5.565)

Ultrasonic monitoring of fibrin clot formation and fibrinolysis in flowing blood

K. G. Guria; S. N. Dzhumaeva; D. A. Ivlev; S. G. Uzlova; G. T. Guria.

Moscow Institute of Physics and Technology

Biophysical Journal

Influence of Ether Bonds and Branched Lipid Tails on Stability of Membranes to Pore Formation

Panov, P. V., Akimov, S. A., Volynsky, P. E., Batishchev, O. V.

Moscow Institute of Physics and Technology

Biophysical Journal

Edge Structure of through Pore in Lipid Membrane

Akimov, S. A., Mukovozov, A. A., Batishchev, O. V.

Moscow Institute of Physics and Technology

2016

Scientific Reports (5.228)

Platelet activation risk index as a prognostic thrombosis indicator

Zlobina K.E., Guria G.Th.

Moscow Institute of Physics and Technology

Thrombosis research (2.447)

Real-time monitoring of drug-induced fibrinolysis under intensive flow conditions in vitro

Dzhumaeva S, Ivlev D, Uzlova S, Guria K, Guria G.

S64-S64 page

Moscow Institute of Physics and Technology

Biophysical Journal

Electrostatic Forces Govern Assembly and Disintegration of the Influenza Virus Protein Scaffold to Provide Tension for Membrane Fusion

Batishchev, O. V., Shilova, L. A., Kachala, M. V., Tashkin, V. Y., Sokolov, V. S., Fedorova, N. V., Baratova, L. A., Knyazev, D. G., Zimmerberg, J., Chizmadzhev, Y. A.

Moscow Institute of Physics and Technology

Biophysical Journal

Mechanism of Line Activity of Ganglioside GM1 on Liquid-Ordered Domains

Galimzyanov, T. R., Alexandrova, V. V., Batishchev, O. V., Lyushnyak, A. S., Akimov, S. A.

Moscow Institute of Physics and Technology

Journal of virology

pH-dependent formation and disintegration of the influenza A virus protein scaffold to provide tension for membrane fusion

Batishchev, O. V., Shilova, L. A., Kachala, M. V., Tashkin, V. Y., Sokolov, V. S., Fedorova, N. V., Baratova, L. A., Knyazev, D. G., Zimmerberg, J., Chizmadzhev, Y. A.

575-585 page

Moscow Institute of Physics and Technology

High-tech medicine

Closed-loop propofol infusion system with arterial pressure control algorithm, a decade of experience

V.M. Magilevets, V.V. Firsov, V.M. Zaiko, I.A.Kozlov.

Moscow Institute of Physics and Technology

Clinical Neurophysiology

Oscillatory activity in nonspecific nuclei of human thalamus during motor and cognitive tasks

U. Semenova, A Lukashev, A. Sedov

e51-52 page

Moscow Institute of Physics and Technology

Neurophysiology

Burst activity features of relay thalamic nuclei in patients with spasmodic torticollis

D. Devetiarov, R. Medvednik, A. Sedov

e80 page

Moscow Institute of Physics and Technology

Movement disorders

Participation of the thalamic CM-Pf complex in movement performance in patients with dystonia

U. Semenova, S. Raeva, A. Sedov

1398–1404 page

Moscow Institute of Physics and Technology

Movement disorders

Single unit activity of globus pallidus during voluntary movements in patients with cervical dystonia

A.S. Sedov, A.A. Tomskiy, A.V. Dekopov, R.S. Medvednik, S.V. Zvorikina

S388 page

Moscow Institute of Physics and Technology

Movement disorders

Single unit activity of medial thalamus during goal-directed motor and cognitive behavior in patients with cervical dystonia

U.N. Semenova, D.A. Devetiarov, R.S. Medvednik, A.S. Sedov

S389 page

Moscow Institute of Physics and Technology

Neuroscience and Behavioral Physiology

fMRI Studies of the Dynamics of Human Brain Reactions on Execution of Voluntary Movements

A.S. Sedov, D.A. Devet’yarov, Yu. N. Semenova, V. V. Zav’yalova, V. L. Ushakov, R. S. Medvednik, M.V. Ublinskii, T.A. Akhadov, 2 and N.A. Semenova

1031-1038 page

Moscow Institute of Physics and Technology

2017

Neuroscience Letters

Rhythmic wrist movements facilitate the soleus H-reflex and non-voluntary air-stepping in humans

Irina A. Solopova, Victor A. Selionov, Egor O. Blinov, Dmitri S. Zhvansky, Yury P. Ivanenko

39-45 page

Moscow Institute of Physics and Technology

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