Fields of research
There are four main directions of research in the lab: oncology, active longevity and age-related neurodegenerative diseases, agricultural biotechnologies, and phagotherapy. One of the key ideas is development of competitive domestic pharmaceuticals with detailed functional characteristic its biological effects on different aspects pro- and eukaryotic cell’ vital functions.
Projects
Oncology
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Executing of preclinical research cycle in context of current State Contract No. 14.N08.11.0122 on “Preclinical studies of low-molecular compound based on inhibitor of BRAF enzyme for metastatic melanoma therapy.”
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Search of new photosensitizers for effective use in photodynamic anticancer therapy. Evaluation of photosensitive activity of new drugs developed on nematodes Caеnorhabditis elegans (C. elegance) as in vivo model.
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Molecular and physical-chemical heterogeneity of tumor exosomes (oncosomes) and its regulation value — next generation cancer diagnostics.
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Joint research project on investigation of new specific tumor invasion mechanisms and drug discovery to combat dissemination of cancer cells (in collaboration with professor Alexis Gautreau, laboratory visiting professor and Principal Investigator at CNRS, Professor at Ecole Polytechnique, Chair of the Biology Dept, Ecole Polytechnique, Paris (France).
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Joint research project on the discovery of innovative drug based on tankyrase activity inhibitor for therapy of solid tumors (in collaboration with professor Stefan Krauss (University of Oslo, Norway).
Active longevity
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Development of 3-D analysis program for biological images and algorithms of aging dynamic estimation on nematodes C. elegance model. Algorithm is based on computer program for measuring physical properties of live nematodes C. elegance acquired in real-time mode. Development of this program allows to accelerate analysis of longevity experimental results and get biological information about test subjects.
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Research on the effect of different compounds extracted from natural vegetable and animal sources on longevity of short-living invertebrate (nematodes C. elegance) and vertebrates (Nothobranchius N.furzeri fish). Acquired data allow to identify new signaling pathways and pick the most perspective substrates for subsequent development of geroprotectors for prolongation and quality improvement of human life.
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Research on signalling pathways and factors influencing DNA repair through aging and under impact of different physical factors.
Agricultural biotechnologies
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Development of methods and means for decomposing of mycotoxins accounting for agricultural animals being in danger including swines, poultry and cattle, which are widespread in the Russian Federation.
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Investigation of new growth regulators for agricultural plants based on lab-developed model systems of Tobacco (Nicotiana tabacum L.) pollen, and cyanobacterias (Chlorella vulgaris), using automatic High Content screening system platform ImageXpress Micro XL (Molecular Devices, USA).
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Validation of biological activity and mechanism of action of new perspective growth modulators for agricultural plants in vivo during the whole development cycle in collaboration with Prof. Dr. K. Palme (University of Freiburg, Germany).
Phagotherapy
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Investigation of bacteriophages to combat microbial pathogens in food and fish processing.
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Pharmacological evaluation of bacteriophages’ therapeutic effect against microbial pathogens resistant to antibiotics.
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Study of bacteriophages’ antimicrobial effect against hypermucoid starins of Klebsiella pneumoniae resistant to antibiotics.
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Study in vitro and in vivo of RNA polymerase inhibitors encoded in genomes of bacteriophages infecting Acinetobacter baumannii.
