Laboratory of Structural Biology of G Protein-Coupled Receptors

Our laboratory applies a multi-disciplinary, structural biological approach in which we combine computational methods with numerous biophysical techniques in order to find an answer to questions concerning the mechanisms of ligand recognition and signal transfer in GPCR.

Activity in the Laboratory of Structural Biology of G Protein-Coupled Receptors is focused on structural and functional research of G-protein Coupled Receptors (GPCR). We apply a multi-disciplinary, structural biological approach in which we combine computational methods with numerous biophysical techniques (crystallography, fluorescence of single molecules, electron microscopy, NMR, mass spectrometry, etc.) in order to find an answer to questions concerning the mechanisms of ligand recognition and signal transfer in GPCR.

 

To implement these activities, the laboratory works in close collaboration with leading research centers in Europe, the USA and China

Vadim Cherezov

Director of the Laboratory of Structural Biology of G-protein Coupled Receptors

Nelli Habibullina

2015

CRYSTAL GROWTH & DESIGN (4.558)

Nucleation and Growth of Membrane Protein Crystals in Meso - A Fluorescence Microscopy Study

Bogorodskiy A., Frolov F., Mishin A., Round E., Polovinkin V., Cherezov V., Gordeliy V., Büldt G., Gensch T., Borshchevskiy V.

Moscow Institute of Physics and Technology

2005

BIOPHYSICAL JOURNAL (3.832)

Water molecules and hydrogen-bonded networks in bacteriorhodopsin - Molecular dynamics simulations of the ground state and the M-intermediate

Grudinin, S, Buldt, G, Gordeliy V, Baumgaertner, A

Moscow Institute of Physics and Technology

PHYSICAL REVIEW E (2.326)

Strength of thermal undulations of phospholipid membranes

Gordeliy, VI, Cherezov, V, Teixeira, J

Moscow Institute of Physics and Technology

JOURNAL OF CHEMICAL INFORMATION AND MODELING (4.068)

The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR-Ligand Interactions

Heifetz A., Chudyk E.I., Gleave L., Aldeghi M., Cherezov V., Fedorov D.G., Biggin P.C., Bodkin M.J.

Moscow Institute of Physics and Technology

BIOCHEMISTRY-MOSCOW (1.353)

Topology of mRNA chain in isolated eukaryotic double-row polyribosomes

Afonina Zh.A., Myasnikov A.G., Khabibullina N.F., Belorusova A.Yu., Menetret J.-F., Vasiliev V.D., Klaholz B.P., Shirokov V.A., Spirin A.S.

Moscow Institute of Physics and Technology

2011

BIOCHEMISTRY (3.194)

Role of the HAMP Domain Region of Sensory Rhodopsin Transducers in Signal Transduction

Gushchin, IY, Gordeliy, VI, Grudinin, S

Moscow Institute of Physics and Technology

2016

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (5.498)

Principal Component Analysis of Lipid Molecule Conformational Changes in Molecular Dynamics Simulations

Buslaev P., Gordeliy V., Grudinin S., Gushchin I.

Moscow Institute of Physics and Technology

Inria, the French National Institute for computer science and applied mathematics

iHuman Institute of ShanghaiTech

University of Southern California

Scripps Research Institute