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Laboratory of Structural Biology of G-protein Coupled Receptors

Activity in the Laboratory of Structural Biology of G-protein Coupled Receptors is focused on structural and functional research of G-protein Coupled Receptors (GPCR). We apply a multi-disciplinary, structural biological approach in which we combine computational methods with numerous biophysical techniques (crystallography, fluorescence of single molecules, electron microscopy, NMR, mass spectrometry, etc.) in order to find an answer to questions concerning the mechanisms of ligand recognition and signal transfer in GPCR.

 

To implement these activities, the laboratory works in close collaboration with leading research centers in Europe, the USA and China.


The laboratory cooperates with the following organizations:

 

The SCRIPPS Research Institute (TSRI), La Jolla, San Diego, USA, is a non-profit research center in the USA that is focused on the research and education in the field of biomedical sciences. The Institute is located in San Diego, California. Its staff includes 3,000 scientists, laboratory technicians, postgraduates and administrative staff, which makes the Institute one of the largest non-profit biomedical organizations in the world. The majority of the research conducted at TSRI is in the fields of cancer biology, cell and molecular biology, chemistry, immunology, infectious diseases, molecular and cellular neurobiology, molecular and experimental medicine, molecular therapy, and metabolic aging.

 

University of Southern California

(USC, Los Angeles, USA) is a private, non-profit research university established in 1880 and located in Los Angeles. More than 35,000 students from 110 countries study at the university at a given time. The University of Southern California is home to research centers and institutes that conduct research in the arts, humanities, social and natural sciences, technology, and engineering. USC spends more than $650 million on research and is among the 10 largest private universities that support research activities at the federal level.

 

French Institute for Research in Computer Science and Automation (INRIA, Institut national de recherché en informatique et en automatique, Grenoble, France) is a national research institute in France that works in the field of computer science, management theory and applied mathematics. INRIA is controlled by the French Ministry of National Education, as well as the Ministry of Economy, Finance and Industry. The organization employs 1,300 researchers, 1,000 Ph.D. students and 500 postdocs.

 

iHumanInstitute, Shanghai, China. iHuman is a modern international research institute located on the territory of Shanghai University of Technology. It is focused on the research of biochemical signal transmission in human cells and unites various scientific approaches and tools for its research, as well as attracts the world's leading experts. The iHuman institute has scientific and research groups in the field of chemical and cellular biology, chemistry, the research of antibodies, computational chemistry, imaging, structural biology, systems biology, and translational biology.


Supervisor: Vadim Cherezov

 

Employees

Cand. Phys.-Math.Sci. Nelly Habibullina

Cand. Phys.-Math.Sci. Sergey Grudinin

Postgraduate Alexey Mishin

Postgraduate Alexandra Luginina

Postgraduate Pavel Buslaev

Engineer Adnan Avavdech

Laboratory Technician Svetlana Ustinova

Sixth-year student Anton Potapenko

Fifth-year student Anastasia Gusach


Contact information:

Address: 127 Laboratory Building, 114 Applied Mathematics Unit, MIPT, 9,Institutskiy per., Dolgoprudny, Moscow Region, 141700.

E-mail: mishinalexej@gmail.com

Tel.: (495) 4087974

Laboratory websitehttp://biomrc.org/

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